Everything We Know About Alex's Absence on 'Grey's Anatomy' (PHOTOS)

Meredith Jacobs

[Warning: The below and gallery above contain MAJOR spoilers for Season 16, Episode 14 of Grey's Anatomy, "A Diagnosis."]

Right now, one of the biggest questions on Grey's Anatomy is what's going on with Alex Karev?

Fans learned in January that Justin Chambers was leaving the ABC medical drama after 15 years and his final episode had already aired. Since Episode 8, "My Shot," there have been a few mentions of him — he's visiting his mother in Iowa, which explains his current absence — but the mystery around what's happening with him deepens each week and with every call from Jo that goes unanswered.

'Grey's Anatomy' EP Says Season 16 Will Provide 'Clarity' on Alex's Fate

'Grey's Anatomy' EP Says Season 16 Will Provide 'Clarity' on Alex's Fate

'We're, episode by episode, illuminating the story of where Alex is,' showrunner Krista Vernoff said.

In the gallery above, we're rounding up everything we know about the MIA doctor.

Grey's Anatomy, Thursdays, 9/8c, ABC