The 17 Most Memorable 'Supernatural' Guest Stars (PHOTOS)

Meredith Jacobs

Sam (Jared Padalecki) and Dean Winchester (Jensen Ackles) only have one more season of saving people, hunting things, the family business on Supernatural.

And some of those people they've saved, things they've hunted, people who have become part of the family business, and other memorable roles have been played by familiar faces.

'Supernatural' Cast on Setting the Tone on Set & the Power of #SPNFamily (VIDEO)

'Supernatural' Cast on Setting the Tone on Set & the Power of #SPNFamily (VIDEO)

Jared Padalecki, Jensen Ackles, Misha Collins, and Alexander Calvert also talk another milestone the show is setting in its final season.

Click through the gallery above for the guest stars we won't forget.

Supernatural, 15th and Final Season Premiere, Thursday, October 10, 8/7c, The CW