When Does ‘Best Medicine’ Season 2 Premiere?
Best Medicine, just a handful of episodes in, became a hit for Fox. And so it was no surprise that the cozy dramedy, an adaptation of the British hit Doc Martin, was renewed for Season 2 in March.
The good news is we won’t have to wait too long for Season 2; it’s premiering earlier in the broadcast season than the show’s first did. Read on for everything we know so far about Best Medicine Season 2, including the premiere date, cast, and more.
When does Best Medicine Season 2 premiere?
The series premiered as part of Fox’s midseason lineup, but it’s moving to the fall for Season 2. It returns on Tuesday, September 22, at 8/7c.
The dramedy’s renewal came in March.
This news wasn’t too surprising, given that it’s doing well for the network. The series premiere was watched by 12.6 million total Multiplatform viewers, and it’s among broadcast’s Top 2 highest-rated drama debuts this season among Adults 18-49, alongside the Fox’s other new series Memory of a Killer.
“Best Medicine quickly became a breakout for us this season, blending sharp humor with real heart,” said Michael Thorn, President of FOX Television Network, in a statement. “Liz Tuccillo brings a distinctive creative voice to the series, and Josh Charles leads an exceptional cast that audiences have embraced. We, along with Propogate, are excited to build on that momentum in Season 2.”
Furthermore, Season 2 will be 14 episodes.
“Best Medicine did so well for us this season. It’s a huge priority to return our sophomore shows as significantly as possible, and getting Best Medicine back on the air in the fall with Doc again on Tuesday nights to us felt like a really powerful move, both for the night as a network, but also in the best interest of Best Medicine as a potentially long-running show for us,” Thorn explained to reporters.
What is Best Medicine about?
The series, based on Doc Martin, follows Josh Charles‘ Dr. Martin Best when he moves from Boston to Port Wenn, where he spent his summers as a child, and becomes its general practitioner. His attitude rubs the locals the wrong way, but they’ll all soon realize that they need each other. And while Martin can diagnose any medical mystery, he’d much rather be left alone, though he is dragged into the town’s business and events. He’s also hiding a debilitating blood phobia, one that makes his job that much harder.
What will happen in Best Medicine Season 2?
When the Fox dramedy returns, Martin is going to have to contend with the aftermath of the medical board putting him under investigation for letting his assistant Elaine (Cree) draw blood (due to his blood phobia).
Looking ahead to Season 2, Martin is “going to have to make some adjustments to his practice, and that might be a new antagonist in town that’s maybe having to watch over him, somebody who has to double-check his work now because they know that he wasn’t on the up and up. So now the main medical board might need to check up on him,” Tuccillo told TV Insider after the Season 1 finale.
There’s also the matter of Martin and Louisa’s (Abigail Spencer) will they/won’t they. Just as he seemed ready to tell her how he really feels, he overheard ex-fiancé Mark (Josh Segarra) offering to have a baby with her (but of course not the full context). He then invited his ex Eden (Eliza Coupe) over.
But Louisa didn’t give Mark an answer. “We’re going to pick up five months later, so you’ll see what she ended up deciding [then],” Tuccillo said.
As for the love triangle/square, “I think it’s just going to get more and more fun and more and more complicated,” she teased.

Francisco Roman/Fox
Who is in the Best Medicine cast?
Best Medicine stars Josh Charles as Dr. Martin Best, Abigail Spencer as schoolteacher Louisa Gavin, Josh Segarra as Sheriff Mark Mylow, Annie Potts as Martin’s aunt Sarah, and Cree as Martin’s assistant Elaine Denton. Stephen Spinella and Jason Veasey, who play husbands Greg Garrison and George Brady who run The Salty Breeze, have been upped to series regulars for Season 2.
“Nothing makes me happier than to make it official with Stephen Spinella and Jason Veasey as our beloved Greg and George. To work with two gentlemen who make every scene funnier, warmer, and more surprising, and happen to be wonderful people themselves, is all a showrunner can ever ask for,” executive producer and showrunner Liz Tuccillo said in a statement.
“Stephen and Jason have become essential to the fabric of Port Wenn, so making them series regulars is beyond thrilling, but welcoming members of the LGBTQ+ community to our permanent family during Pride month is the cherry on top.” said executive producer Rodney Ferrell.
Recurring guest stars in Season 1 include Didi Conn as councilwoman Geneva Potter, Clea Lewis as pharmacist Sally Mylow, Cindy De La Cruz as schoolteacher Jeannie, John DiMaggio as handyman Bert Large, Carter Shimp as Bert’s son Al Large, and Wattson as Copernicus, the dog that won’t leave Martin alone. Plus, the original Doc Martin himself, Martin Clunes, made a special guest appearances as Martin’s father, Dr. Robert Best. Clunes will be back in Season 2.
Conversation57 Comments
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B
It's the best show ever in the whole world... ❤️❤️ I look forward to watching at every week my whole family does... It's so relatable... I can't wait I'm so glad to hear season 2 is coming... I don't ever want to see it end... I look forward to the new show every week.. so glad it's on an hour. ❤️❤️❤️
52
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P
It reminds me of a Maine domiciled “northern exposure- all the quirky characters and the weekly escapades. Enjoying so far.
37
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G
We love it!!! It’s so good. Thx you. I don’t compare the two shows because each one is different. It’s like comparing Cheers to Friends. They are both great but different in so many ways. You have to be open minded. Thank you for a great show.
36
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F
This has become my favorite TV series right from the first episode.
Having been raised close to Boston, and then enjoying a sea side vacation home over twenty-five years ago in Corea, Maine, has made it much easier for me to feel and identify with Best Medicine
With any new series, it’s natural to see bias coming from viewers of the original series,
as they can find it more difficult to relate to something new. For viewers who have not seen the original series, including myself, it’s much easier to get a completely new perspective, which can be even more uplifting and relatable, as this one takes place here, in the United States, which is not meant to take anything away from the quality of the original series in Britain.
The popularity of Josh Charles, from The Good Wife, and also, his seemingly ease at moving back and forth through comedy and drama may give this series the potential for longevity, depending of course, on the writing, and the present and future cast.
Most importantly, though, is whether FOX chooses to reward it’s long-term TV viewers by protecting this show, with a favorable time slot, and allowing it to be discovered and grow it’s audience.
28
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E
I absolutely love this show. It's hilarious, touching, sweet, and the acting is great! Each episode gets better and better.
22
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J
At the beginning I watched the 1st episode. I am a big fan of Doc Martin and I didn't care for Best Medicine. After watching the full 1st season I found I like it but not as much as Doc Martin. I don't care for this version of the sheriff.
The Large father and son play a small role. I also don't care for such a small town having some sort of festival almost every episode. We'll the Doc let's the dog hang around and he does help the folks in the Village, even though it was filmed on the Hudson River. Not many lobster there. Anyways it's entertaining. Glad for a 2nd season.
17
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M
I did not like it at first BUT gave it a chance. As you get to know the charactors it is getting better. Each show is better then the last. So I am glad it got renewed.
16
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Q
I really enjoyed the show. It is fun, great characters, love them all. He is an excellent "doctor" for the show. Can't wait to see more episodes. He is not as "rude" as the original Doc Martin, he plays an excellent doctor trying to cope with his condition. The show where his father (Martin Clunes original Doc Martin) is visiting was interesting. Martin Clunes was more verbal as opposed to when he played Doc Martin. Dr. Best is so good at his role. Of course, the way tv works, if people like the show, they cancel it. For some strange reason, the suits and the public do not see eye to eye on what the public enjoys watching. Please tell the suits that this is a really nice show, no bad language, no nudity. Oh wait, maybe that's what the suits think the tv watchers want. Think again, suits.
15
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L
I absolutely LOVE this show and look forward to it every week. It's so relatable. Just an awesome show
13
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C
I've watched the original series - all 10 seasons over and over. With the characters, their stories and their chemistry, there will never be another adaptation of Doc Martin for me. No desire to watch the new series.
8
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J
I love the sheriff. He's quirky and sweet.
6
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T
Not a patch on Doc Martin, but would be better if you got rid of the dizzy receptionist and sheriff.
6
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T
Especially the receptionist. Not likable at all to me and isn’t getting any better. Show is coming along and I like the nuggets that show up from the original. It took then 3 tries in the original to get the right receptionist so I remain hopeful.
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I
I bailed after four episodes. I got tired of the town people constantly yelling at the new doctor. The vibe was too negative.
5
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P
This is an extremely boring show, the mind boggles as to why so many people seem to be watching it.
5
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L
I'm really looking forward to Best Medicine's return. I was so disappointed when it ended. I don't usually like series but I loved this show. So happy there wasn't canned laughter with it. I can't stand shows that have it.
4
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C
Did not care for the series. After following Dr. Martin for years I think it is a poor copy of a very good
British series. Too many characters as bad copies of the original. Also way too many plots and people
doing weird things in each episode.
4
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S
We Love, Love, Love Best Medicine!!! Our family have been going through breast cancer treatments. Best Medicine is a way of laughing at the silliest of things. It makes our hearts lighter and one day we would love to live in a place like Port Wenn.
3
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J
I so look forward to Tuesday nights because of this show!! All the characters are funny with sincere hearts. I already can't wait for season 2. Stellar job everyone!!
3
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D
LOVE this show. We need good shows like this. Especially now! So happy it was picked up for another season!!
2
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D
It's not as good as uk Doc Martin but does make me smile !!
That sheriff is a bloody numpty tho !!
2
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E
I am so glad that this show is coming back in the fall. It's one of the best shows ever!! Let's keep it going!!
2
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M
I binged this over the long weekend. Excellent show! Excellent characters. I was so happy to find that there will be a season 2. I would have been so disappointed!!
2
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J
I love Best Medicine! What an awesome show. Funny, clever, thought provoking. I hope it contributes for years to come.
2
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K
Love this show best show. I’ve seen on TV in years. Can’t wait for season two!!
2
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J
We like it a lot, can't wait till the next season! We binged watched the first season.
2
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J
I have thoroughly enjoyed watching Best Medicine. This is the best show that was created in a while. Very happy to hear it will return for another season.
2
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J
Love Best Medicine!! The story plots for the different characters keep me intrigued. The actors also play their roles perfectly. Can't wait for it to start back up again.
2
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V
I💖Best Medicine!!
2
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C
Not happy with gay men kissing. Too much more and you'll lose viewers. I have no problem with anyone's relationship but keep it private.
1
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H
I really liked Doc Martin, which I give a solid 4 out of five stars. Maybe 4-1/2.
While I like Best Medicine, somehow, I just preferred the English version. Hopefully, Best will improve with time.
I give Best Medicine 3 stars.
1
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B
This is by far one of the best shows on TV! So happy it’s returning.
1
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J
I wholeheartedly agree with you!
1
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S
Love the show. I'm getting annoyed with sitcoms having to include gay men... why aren't there more lesbians instead? Its always guys which is a turnoff when they kiss. Sorry... I just don't care for that visual. Leave the personal stuff in the bedroom
1
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J
Terrible show
Just a copy of Doc Martin
BE ORIGINAL!!.Could have been better if they had done that. I don't need to see a rerun of Doc Martin
1
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B
At first I was unsure but with Elaine and the gay guys I was so impressed cause it was joyful and unpredictable something to think about and laugh with. And can’t wait for the next episode. Thsnk you Josh Charles. You are the best ♥️❤️🩶🩵
1
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L
LOVE the show and thrilled Season 2 is coming! Great cast.
1
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D
It got renewed.
1
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W
I love this show I can’t wait for season 2.
1
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S
It was terrific.
1
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C
The show is growing on me. I just wish they’d eliminate the town jerk who keeps threatening the doctor. Just annoying as heck. And the sheriff is so much a simpleton, he’s hard to take. But I will be impatiently waiting for the new season.
1
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W
I love this show .I have actually changed plans to keep from missing one episode can't wait for season 2
1
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B
Love this show! Wish it had more episodes!
1
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L
I discovered the British show Doc Martin on PBS several years ago and loved it! Hated to see it finally close. When I discovered Best Medicine, I thought "Hm, that looks very familiar and then realized that it was a new version here in the states. Love that show! Josh Charles is awesome in the role and what a treat for Martin Clune to make an guest appearance! Long live Best Medicine!
1
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A
HE IS A LAWYER NOT A DOC.
1
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P
I got to binge watch Season 1 on Netflix. Love it.
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C
And get rid of Eden
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C
Love the show & characters. Great escape from today’s headlines. Looking forward to new season.
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N
Picks up 5 months later..I don't do time jumps so that's me out. I consider them to be lazy, sloppy writing and I won't reward shows that use them by continuing to watch.
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C
I love the show. It is different in a good way, like dealing with real people.
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S
Love this show. The characters are real people living in a small close knit community who are trying to bring this stubborn doctor into the fold
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C
I really enjoy the show. Can’t wait to see the next season.
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J
I like Best Medicine way better than Doc Martin. It’s much more believable and I like the characters better. Both were good but Best Medicine wins in my book.
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B
I really enjoy this show
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T
Love Best Medicine great show I never want to miss. Super cast good plots. Love it. Thank God it’s back fir season 2.
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L
I just simply love the show. I am a true crime watcher constantly, so this show is a breath of fresh air for me and I absolutely love it💙💯💙
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L
Absolutely love this show! I look forward to Tuesdays just to watch Can’t’ wait for Season 2 All the characters are great




