‘Memory of a Killer’: Patrick Dempsey & Cast Detail Dangers of Hitman Angelo Losing His Memory (VIDEO)

Fox’s newest thriller is building out its cast. On Monday, December 15, the network released a behind-the-scenes video for Memory of a Killer starring Patrick Dempsey (who is returning to broadcast television), and it shows the cast breaking down the show and the very dangerous problem that his character faces.

Dempsey’s character, Angelo, is a hitman living a double life — and he’s been able to keep his professional and personal lives separate until now, when he begins losing his memory (he has family history of Alzheimer’s). Michael Imperioli plays Dutch, who runs the criminal operation for which Angelo works out of his restaurant. The two men grew up together.

“They have a very close bond,” says Imperiolo in the video. “They know an awful lot about each other, but they don’t know everything.” For example? Dutch doesn’t know Angelo has a family. Watch the video above for more from the cast about the series and Angelo’s double life as well as clips from the drama.

Read on for everything we know about Memory of a Killer, from the cast to a premiere date and more.

When will Memory of a Killer premiere?

The new series will have a special two-night premiere: on Sunday, January 25, 2026, at 10/9c, after theNFC Championship Game, then in the regular time period on Monday, January 26, at 9/8c.

Who stars in Memory of a Killer?

Patrick Dempsey has been cast as the main character, Angelo Flannery/Doyle, a hitman leading a dangerous double life while hiding an even deadlier personal secret: that he has developed early onset Alzheimer’s.

Joining him is Michael Imperioli as Dutch, an accomplished Italian chef who owns a restaurant in the Bronx, a stalwart establishment that is also a front for Dutch’s less sociable activities — such as running a criminal enterprise. As ruthless and mercurial as he is affable, Dutch is Angelo’s oldest friend, as well as his employer — he gives Angelo the targets for his hits. In a business as dangerous as theirs, Angelo must trust Dutch. But being trustworthy isn’t one of Dutch’s more dependable qualities.

Richard Harmon plays Joe, a hitman on the rise working for Angelo and Dutch in their clandestine crime business. Joe gets stuck with the grunt work – gathering recon and sorting getaway plans – but that puts him in prime position to witness Angelo’s Alzheimer’s decline. Joe knows he could make or break Angelo, but he also knows that choice could cost him everything.

Odeya Rush plays Angelo’s daughter, Maria. “Married young and pregnant, it seems she’s chosen a quiet life. But something stirs in her – a yearning for adventure. Might she be a chip off the old hitman block? Angelo is Maria’s everything, so when his mind begins to falter, she’s right there by his side to care for him. As she gets closer and closer to her father, she’ll find that being close to Angelo is a dangerous place to be,” reads the character description, via Deadline.

Daniel David Stewart plays Jeff, Maria’s husband, “an inventor with self-confidence but no investors, he’s in no rush to get a regular job or treat his father-in-law with respect. With Maria pregnant and a growing family to support, nothing could be better than having Grandpa around the corner, if only he wasn’t a hitman.”

Peter Gadiot stars as Dave, “a local police detective in sleepy Hudson Springs who has no idea a world class hitman is living there right under his nose, or that Angelo is that hitman. Dave investigated the drunk driving accident that took Angelo’s wife from him five years ago, and since then he and Angelo have become great friends. Further complicating things, Dave is secretly in love with Angelo’s married daughter, Maria.”

Gina Torres will “heavily” recur as Linda Grant, described by Fox as “a mercurial, seasoned and brilliantly tenacious FBI Agent who becomes a major antagonist for Angelo across Season 1.” Her character description continues, “When Grant begins investigating one of Angelo’s kills, it puts them on a collision course that will see Grant come perilously close to unmasking Angelo’s many secrets and threatening everything he holds dear.”

The series is produced by Warner Bros. Television and Fox Entertainment. It’s from Ed Whitmore and Tracey Malone, who executive produce alongside Cathy Schulman of Welle Entertainment. Arthur Sarkissian and Martin Campbell are also executive producers, along with Peter Bouckaert of Eyeworks.

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What is Memory of a Killer about?

The new dramatic thriller is inspired by the 2003 award-winning Belgian film De Zaak Alzheimer (La Memoire Du Tueur). It follows Dempsey’s “hitman who develops early onset Alzheimer’s. Losing your memory is a devastating hammer blow for anyone, but for Angelo Ledda, the stakes couldn’t be higher. His hitman job would be perilous enough, but there’s an added pressure. Angelo lives two totally separate lives — fearsome NYC hitman and sleepy upstate Cooperstown photocopier salesman and father. Having built and maintained a brick wall between his two worlds, Angelo has seamlessly juggled and compartmentalized for years. But now that’s all about to change. Because Alzheimer’s is a foe he can’t outrun, and he knows too well how this ends, as his older brother is already lost to the condition.”

The series description continues, “Angelo is exceptionally resourceful and talented, the best of the best. But he’s about to be tested like never before — and now every minute counts. This is only made more difficult when he discovers that his wife’s recent death may not have been an accident. So, when someone comes after his daughter — who is pregnant — it’s clear the wall between his lives has been breached. Angelo must stop whoever’s coming for his family by searching his past hits for clues, and the list is very long. Now Angelo must hunt down his mortal enemy while continuing to carry out hits without giving away his diagnosis and still making it home in time to cook dinner for his daughter. Memory of a Killer is a redemptive story about a man who is losing his memory but gaining a conscience. Because Angelo knows he must stop history from repeating itself and save his family — before he forgets the past.”

During a call with reporters on Sunday, May 11, Michael Thorn, President, FOX Television Network, FOX Entertainment, called it “a dramatic thriller with a noisy unrelenting hook that immediately grabbed our attention. In the spirit of 24 and House, Memory of a Killer is anchored by a bold lead with all the makings of another undeniable signature Fox character. In addition to the visceral qualities of the script, it’s one of the most emotionally charged stories I’ve seen in a long time.”

Is there a Memory of a Killer trailer?

Yes, and you can watch it below. It offers a look at his character’s double life.

“My mind, it hasn’t been right,” Angelo says. “I’m afraid. I can’t afford to be afraid.” See him in action as a hitman, first looks at Gina Torres and Michael Imperioli‘s characters, and more: