'Grey's Anatomy' Hits a New Milestone — A Look Back at 6 Favorite Moments (PHOTOS)

Ileane Rudolph

On February 28, Grey's Anatomy will air its 332nd episode (8/7c, ABC) and surpass ER as TV’s longest-running primetime medical show.

"This is something we never would have thought about achieving during the shooting of the pilot," says original cast member Chandra Wilson (Dr. Bailey), who also directed the historic installment, in which the doctors celebrate Catherine's (Debbie Allen) life-saving surgery.

We spotlight some unforgettable favorites.

'Grey's Anatomy' Season 16 Renewal Very Likely, Says ABC President

'Grey's Anatomy' Season 16 Renewal Very Likely, Says ABC President

Mostly because of Ellen Pompeo's two year-deal with ABC Studios.

Grey's Anatomy, Thursdays, 8/7c, ABC