7 Most Heartbreaking 'Grey's Anatomy' Breakups (PHOTOS)

Zoe Jewell

Grey’s Anatomy may be a medical drama, but it’s definitely a show all about love and relationships. While some romances have lasted a long time — and let’s be honest, others have lasted too long — there have been those select few relationships that audiences seemed to connect with.

Whether it was two unlikely people getting together or a romance born out of friendship, Grey’s has always managed to make us feel like love is possible, no matter what. However, the show’s also manages to break our heart when the powers-that-be decide a relationship is done.

Though there are countless relationships that could go on this list, click through the gallery to see the seven most heartbreaking breakups over the years.

Grey's Anatomy, Season 16 Premiere, Thursday, September 26, 8/7c, ABC

7 Things That Need to Happen in 'Grey's Anatomy' Season 16 (PHOTOS)

7 Things That Need to Happen in 'Grey's Anatomy' Season 16 (PHOTOS)

Here's what we'd like to see go down when the ABC medical drama returns this fall.