‘Best Medicine’ Renewed for Season 2

Josh Charles as Martin —'Best Medicine' Season 1 Episode 4 'All the World's Ablaze'
Francisco Roman/Fox

Best Medicine, just a handful of episodes in, is already a hit for Fox. But will the cozy dramedy, an adaptation of the British hit Doc Martin, return for Season 2?

Yes! The good news was announced on March 2. Its 12-episode Season 2 will debut in 2026-2027.

Best Medicine quickly became a breakout for us this season, blending sharp humor with real heart,” said Michael Thorn, President of FOX Television Network, in a statement. “Liz Tuccillo brings a distinctive creative voice to the series, and Josh Charles leads an exceptional cast that audiences have embraced. We, along with Propogate, are excited to build on that momentum in Season Two.”

Read on for everything we know so far about Best Medicine Season 2, including a premiere date, cast, and more.

Is Best Medicine renewed for Season 2?

Yes, Fox renewed the dramedy on March 2.

This news wasn’t too surprising, given that it’s doing well for the network. The series premiere was watched by 12.6 million total Multiplatform viewers, and it’s among broadcast’s Top 2 highest-rated drama debuts this season among Adults 18-49, alongside the Fox’s other new series Memory of a Killer.

When will Best Medicine Season 2 premiere?

The series premiered as part of Fox’s midseason lineup, but that doesn’t necessarily mean it will again. Fox could choose to move it to the fall schedule. All we know is Season 2 will air in the 2026-2027 season.

What is Best Medicine about?

The series, based on Doc Martin, follows Josh Charles‘ Dr. Martin Best when he moves from Boston to Port Wenn, where he spent his summers as a child, and becomes its general practitioner. His attitude rubs the locals the wrong way, but they’ll all soon realize that they need each other. And while Martin can diagnose any medical mystery, he’d much rather be left alone, though he is dragged into the town’s business and events. He’s also hiding a debilitating blood phobia, one that makes his job that much harder.

Who is in the Best Medicine cast?

Best Medicine stars Josh Charles as Dr. Martin Best, Abigail Spencer as schoolteacher Louisa Gavin, Josh Segarra as Sheriff Mark Mylow, Annie Potts as Martin’s aunt Sarah, and Cree as Martin’s assistant Elaine Denton.

Recurring guest stars include Didi Conn as councilwoman Geneva Potter, Clea Lewis as pharmacist Sally Mylow, Stephen Spinella and Jason Veasey as the happily married proprietors of The Salty Breeze, Greg Garrison and George Brady, Cindy De La Cruz as schoolteacher Jeannie, John DiMaggio as handyman Bert Large, Carter Shimp as Bert’s son Al Large, and Wattson as Copernicus, the dog that won’t leave Martin alone. Plus, the original Doc Martin himself, Martin Clunes, makes a special guest appearances as Martin’s father, Dr. Robert Best.