The 14 Most Famous ‘Grey’s Anatomy’ Guest Stars Ever (PHOTOS)
Grey’s Anatomy has had countless guest stars over the years, and while some of them have gone unremembered, others have become major A-list stars.
Whether they went on to win Emmys, get nominated for Oscars, or star in mega-hit movies, Grey’s certainly knows how to find the best talent out there.
From veterans to up-and-comers, check out the gallery above for 14 of the biggest celebs to ever appear on the show.
Grey’s Anatomy, Season 16 Premiere, Thursday, September 26, 8/7c, ABC
Mandy Moore
Character: Mary Portman, a patient who was inside Grey Sloan Memorial during the shooting
Season(s): Season 6, 7
Faye Dunaway
Character: Margaret Campbell, the first female surgeon at Grey Sloan Memorial
Season(s): Season 5
Christina Ricci
Character: Hannah Davies, the paramedic who helped stop the bleeding of a patient by putting her hand in his chest
Season(s): Season 2
Kyle Chandler
Character: Dylan Young, leading member of the bomb squad who was killed after the bomb exploded
Season(s): Season 2, 3
Abigail Breslin
Character: Megan Clover, a girl who comes into the hospital who does not experience pain
Season(s): Season 3
Elisabeth Moss
Character: Nina Rogerson, a very protective daughter who was concerned for her mother’s well-being
Season(s): Season 3
Jesse Plemons
Character: Jake Burton, a patient who had a brain tumor called by lionitis, which causes calcium to build up in the skull
Season(s): Season 2
Bernadette Peters
Character: Sarabeth Breyers, a woman who came to the hospital following a car accident
Season(s): Season 5
Geena Davis
Character: Nicole Herman, the Head of Fetal Surgery at Grey Sloan Memorial
Season(s): Season 11, 14
Laurie Metcalf
Character: Beatrice Carver, a patient who had terminal cancer
Season(s): Season 2
Demi Lovato
Character: Hayley May, a patient incorrectly diagnosed with schizophrenia
Episode(s)/Season(s): Season 6
Millie Bobby Brown
Character: Ruby, a little girl who came to the hospital to take care of her mother
Episode(s)/Season(s): Season 11
Sarah Paulson
Character: Young Ellis Grey, Meredith’s mother
Episode(s)/Season(s): Season 6
Tessa Thompson
Character: Camille Travis, Richard Webber’s niece who was diagnosed with ovarian cancer at 14
Episode(s)/Season(s): Season 2
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