It's the Beginning of the End in the 'How to Get Away With Murder' Premiere (PHOTOS)

The Season 6 premiere of How to Get Away With Murder picks up as Annalise (Viola Davis) struggles with the personal toll that Laurel (Karla Souza) and Christopher’s disappearance has taken on everyone.

Meanwhile, the remaining Keating 4, Oliver (Conrad Ricamora), Frank (Charlie Weber) and Bonnie (Liza Weil) disagree on the possible reasons behind Laurel’s disappearance.

'How to Get Away With Murder' EP on Giving Annalise a Proper Ending in Season 6

Exec producer Peter Nowalk teases that every crime 'will have to be paid for' in the ABC drama's final season.

Plus, Tegan (Amirah Vann) handles the aftermath of Emmett’s apparent poisoning, and Gabriel (Rome Flynn) wants to take his budding relationship with Michaela (Aja Naomi King) to the next level.

Click through the gallery above for a sneak peek at the final season!

How to Get Away With Murder, Season 6 Premiere, Thursday, September 26, 10/9c, ABC