This episode — in which House draws upon personal experience to give a lecture about three leg pain patients — won creator David Shore the 2015 Emmy for Outstanding Writing for a Drama Series.
“Autopsy” (Season 2, Episode 2)
In this installment, future Pretty Little Liars star Sasha Pieterse plays a young girl with terminal cancer who undergoes therapeutic hypothermia so the docs can find a blood clot.
“Euphoria: Part 2” (Season 2, Episode 21)
Foreman (Omar Epps) reaches his breaking point with a by-the-book Cuddy (Lisa Edelstein) after he’s diagnosed with the same mystery disease that killed a patient in the first half of this two-parter.
“No Reason” (Season 2, Episode 24)
In the Season 2 finale — Shore’s directorial debut — a disgruntled former patient shoots House, and as the doc recovers, he struggles to separate hallucination from reality.
“House’s Head” (Season 4, Episode 15)
This episode — which earned two Emmy nominations and a win for director Greg Yaitanes — follows House as he eventually identifies former coworker Amber (Anne Dudek), who was dating Wilson (Robert Sean Leonard), as the bus crash victim dying in a vision of his.
“Wilson’s Heart” (Season 4, Episode 16)
After the events of the previous episode, the race is on to save Amber’s life in this Season 4 finale. The team’s efforts are unsuccessful, and the fact that Amber was only on the bus because of House drives a wedge between him and Wilson.
“Under My Skin” (Season 5, Episode 23)
Still haunted by Amber even after her death, House goes to extreme measures to rid himself of his hallucinations while he and the team work to save the life of a ballerina.
“Both Sides Now” (Season 5, Episode 24)
As Cameron (Jennifer Morrison) and Chase (Jesse Spencer) get hitched, an addled House admits defeat and has Wilson drive him to a psychiatric hospital in this Season 5 finale.
“Broken” (Season 6, Episode 1/2)
This two-part Season 6 premiere — which earned the WGA Awards’ Best Episodic Drama prize — shows House’s time at Mayfield Psychiatric Hospital and his interactions with manic-depressive roommate Alvie, played by Hamilton’s Lin-Manuel Miranda.
“Everybody Dies” (Season 8, Episode 22)
House confronts his demons, engineers a resurrection, and embarks on a new adventure with Wilson in this series finale, which featured the reappearances of many of the show’s most important characters.
Never was there ever a TV doctor so grumpy, so misanthropic, so antisocial as Dr. Gregory House of Princeton–Plainsboro Teaching Hospital. And audiences went wild for the Hugh Laurie character.
From 'ER' to 'New Amsterdam,' we're breaking down their accuracy.
In celebration of House’s 15th anniversary on November 16, we’re spotlighting the 10 best episodes of the series, as rated by IMDb voters. Check out the gallery above to see those 10 standout installments in chronological order.