The 14 Most Famous 'Grey's Anatomy' Guest Stars Ever (PHOTOS)
Mandy Moore
Character: Mary Portman, a patient who was inside Grey Sloan Memorial during the shootingSeason(s): Season 6, 7
Faye Dunaway
Character: Margaret Campbell, the first female surgeon at Grey Sloan MemorialSeason(s): Season 5
Christina Ricci
Character: Hannah Davies, the paramedic who helped stop the bleeding of a patient by putting her hand in his chestSeason(s): Season 2
Kyle Chandler
Character: Dylan Young, leading member of the bomb squad who was killed after the bomb explodedSeason(s): Season 2, 3
Abigail Breslin
Character: Megan Clover, a girl who comes into the hospital who does not experience painSeason(s): Season 3
Elisabeth Moss
Character: Nina Rogerson, a very protective daughter who was concerned for her mother’s well-beingSeason(s): Season 3
Jesse Plemons
Character: Jake Burton, a patient who had a brain tumor called by lionitis, which causes calcium to build up in the skullSeason(s): Season 2
Bernadette Peters
Character: Sarabeth Breyers, a woman who came to the hospital following a car accidentSeason(s): Season 5
Geena Davis
Character: Nicole Herman, the Head of Fetal Surgery at Grey Sloan MemorialSeason(s): Season 11, 14
Laurie Metcalf
Character: Beatrice Carver, a patient who had terminal cancerSeason(s): Season 2
Demi Lovato
Character: Hayley May, a patient incorrectly diagnosed with schizophreniaEpisode(s)/Season(s): Season 6
Millie Bobby Brown
Character: Ruby, a little girl who came to the hospital to take care of her motherEpisode(s)/Season(s): Season 11
Sarah Paulson
Character: Young Ellis Grey, Meredith’s motherEpisode(s)/Season(s): Season 6
Tessa Thompson
Character: Camille Travis, Richard Webber’s niece who was diagnosed with ovarian cancer at 14Episode(s)/Season(s): Season 2
Grey’s Anatomy has had countless guest stars over the years, and while some of them have gone unremembered, others have become major A-list stars.
Whether they went on to win Emmys, get nominated for Oscars, or star in mega-hit movies, Grey’s certainly knows how to find the best talent out there.
From veterans to up-and-comers, check out the gallery above for 14 of the biggest celebs to ever appear on the show.
Grey's Anatomy, Season 16 Premiere, Thursday, September 26, 8/7c, ABC
6 Strongest 'Grey's Anatomy' Relationships Going Into Season 16 (PHOTOS)
While some romances are heading south, there are some still going strong!
