The 14 Most Famous 'Grey's Anatomy' Guest Stars Ever (PHOTOS)

Zoe Jewell

Grey’s Anatomy has had countless guest stars over the years, and while some of them have gone unremembered, others have become major A-list stars.

Whether they went on to win Emmys, get nominated for Oscars, or star in mega-hit movies, Grey’s certainly knows how to find the best talent out there.

From veterans to up-and-comers, check out the gallery above for 14 of the biggest celebs to ever appear on the show.

Grey's Anatomy, Season 16 Premiere, Thursday, September 26, 8/7c, ABC

6 Strongest 'Grey's Anatomy' Relationships Going Into Season 16 (PHOTOS)

6 Strongest 'Grey's Anatomy' Relationships Going Into Season 16 (PHOTOS)

While some romances are heading south, there are some still going strong!