The 14 Most Famous ‘Grey’s Anatomy’ Guest Stars Ever (PHOTOS)

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Greys Guest Stars
Guest1
ABC

Mandy Moore

Character: Mary Portman, a patient who was inside Grey Sloan Memorial during the shooting

Season(s): Season 6, 7

Guest2
ABC

Faye Dunaway

Character: Margaret Campbell, the first female surgeon at Grey Sloan Memorial

Season(s): Season 5

Guest3
ABC

Christina Ricci

Character: Hannah Davies, the paramedic who helped stop the bleeding of a patient by putting her hand in his chest

Season(s): Season 2

Guest4
ABC

Kyle Chandler

Character: Dylan Young, leading member of the bomb squad who was killed after the bomb exploded

Season(s): Season 2, 3

Guest5
ABC

Abigail Breslin

Character: Megan Clover, a girl who comes into the hospital who does not experience pain

Season(s): Season 3

Guest6
ABC

Elisabeth Moss

Character: Nina Rogerson, a very protective daughter who was concerned for her mother’s well-being

Season(s): Season 3

Guest7
ABC

Jesse Plemons

Character: Jake Burton, a patient who had a brain tumor called by lionitis, which causes calcium to build up in the skull

Season(s): Season 2

Guest8
ABC

Bernadette Peters

Character: Sarabeth Breyers, a woman who came to the hospital following a car accident

Season(s): Season 5

Screen Shot 2019-08-27 at 3
ABC

Geena Davis

Character: Nicole Herman, the Head of Fetal Surgery at Grey Sloan Memorial

Season(s): Season 11, 14

Guest9
ABC

Laurie Metcalf

Character: Beatrice Carver, a patient who had terminal cancer

Season(s): Season 2

Demi Lovato

Character: Hayley May, a patient incorrectly diagnosed with schizophrenia

Episode(s)/Season(s): Season 6

Guest12
ABC

Millie Bobby Brown

Character: Ruby, a little girl who came to the hospital to take care of her mother

Episode(s)/Season(s): Season 11

Guest13
ABC

Sarah Paulson

Character: Young Ellis Grey, Meredith’s mother

Episode(s)/Season(s): Season 6

Guest14
ABC

Tessa Thompson

Character: Camille Travis, Richard Webber’s niece who was diagnosed with ovarian cancer at 14

Episode(s)/Season(s): Season 2

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Grey’s Anatomy has had countless guest stars over the years, and while some of them have gone unremembered, others have become major A-list stars.

Whether they went on to win Emmys, get nominated for Oscars, or star in mega-hit movies, Grey’s certainly knows how to find the best talent out there.

From veterans to up-and-comers, check out the gallery above for 14 of the biggest celebs to ever appear on the show.

Grey’s Anatomy, Season 16 Premiere, Thursday, September 26, 8/7c, ABC

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