‘NCIS’ Celebrates 350 Episodes — See How the Cast Has Changed (PHOTOS)

Meaghan Darwish April 17, 2018, 5:30 pm

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ncis-1-mark-harmon — Vince Bucci/Getty Images

THEN (2004): Mark Harmon

NCIS - Mark Harmon — Kevin Lynch/CBS

NOW (2017): Mark Harmon

David McCallum attends Juror Appreciation Day — Matthew Peyton/Getty Images

THEN (2002): David McCallum

David McCallum of the CBS series NCIS — John Paul Filo/CBS

NOW (2017): David McCallum

Mark Mainz/Getty Images

THEN (2003): Pauley Perrette

ncis-pauley-perette-1 — Kevin Lynch/CBS

NOW (2017): Pauley Perrette

Museum of Television and Radio Cocktail Party — Stephen Shugerman/Getty Images

THEN (2004): Michael Weatherly

ncis-bull-michael-weatherly — Patrick Harbron/CBS

NOW (2016): Michael Weatherly

Cote De Pablo arrives to the 'The Jury' launch party — Bryan Bedder/Getty Images

THEN (2003): Cote de Pablo

Cote de Pablo attends the Centerpiece Gala Premiere 'The 33' — Mark Davis/Getty Images

NOW (2015): Cote de Pablo

Actor Sean Murray and actress Pauley Perrette attend the NCIS 100th Episode celebration — Michael Buckner/Getty Images

THEN (2007): Sean Murray

Sean Murray of the CBS series NCIS — Kevin Lynch/CBS

NOW (2017): Sean Murray

20 Annual Casting Society Of America Artios Awards — Frederick M. Brown/Getty Images

THEN (2004): Rocky Carroll

Rocky Carroll of the CBS series NCIS — Kevin Lynch/CBS

NOW (2017): Rocky Carroll

Brian Dietzen arrives at the 2010 PaleyFest — Alberto E. Rodriguez/Getty Images

THEN (2010): Brian Dietzen

Kevin Lynch/CBS

NOW (2017): Brian Dietzen

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It’s the end of an era for NCIS fans, as Pauley Perrette prepares to leave the long-running CBS series. But before that, the CBS series has something good to celebrate: 350 episodes!

On April 17, the long-running procedural hits the major milestone, reminding us just how much the show and its cast have changed through the years. In fact, Perette isn’t the first to make her exit — in the show’s earlier years, Mark Harmon was flanked by the likes of Michael Weatherly (Bull) and Cote de Pablo, both who have since left.

Here's What We Know About Pauley Perrette's Final 'NCIS' Episodes as Abby

Still, a number of favorites are still around, such as Sean Murray and David McCallum. And in honor of the big episode, we’re taking a look at the stars who made NCIS what it is today from way back when to now. Click through the gallery above for them all!

NCIS, 350th Episode airs Tonight, Tuesday, April 17, 8/7c, CBS