‘NCIS’ Celebrates 350 Episodes — See How the Cast Has Changed (PHOTOS)

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THEN (2004): Mark Harmon

NCIS - Mark Harmon
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NOW (2017): Mark Harmon

David McCallum attends Juror Appreciation Day
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THEN (2002): David McCallum

David McCallum of the CBS series NCIS
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NOW (2017): David McCallum

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THEN (2003): Pauley Perrette

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NOW (2017): Pauley Perrette

Museum of Television and Radio Cocktail Party
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THEN (2004): Michael Weatherly

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NOW (2016): Michael Weatherly

Cote De Pablo arrives to the 'The Jury' launch party
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THEN (2003): Cote de Pablo

Cote de Pablo attends the Centerpiece Gala Premiere 'The 33'
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NOW (2015): Cote de Pablo

Navy NCIS: Naval Criminal Investigative Service Celebrates Their 100th Episode
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THEN (2007): Sean Murray

Sean Murray of the CBS series NCIS
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NOW (2017): Sean Murray

20 Annual Casting Society Of America Artios Awards
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THEN (2004): Rocky Carroll

Rocky Carroll of the CBS series NCIS
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NOW (2017): Rocky Carroll

Brian Dietzen arrives at the 2010 PaleyFest
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THEN (2010): Brian Dietzen

Brian Dietzen
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NOW (2017): Brian Dietzen

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It’s the end of an era for NCIS fans, as Pauley Perrette prepares to leave the long-running CBS series. But before that, the CBS series has something good to celebrate: 350 episodes!

On April 17, the long-running procedural hits the major milestone, reminding us just how much the show and its cast have changed through the years. In fact, Perette isn’t the first to make her exit — in the show’s earlier years, Mark Harmon was flanked by the likes of Michael Weatherly (Bull) and Cote de Pablo, both who have since left.

Still, a number of favorites are still around, such as Sean Murray and David McCallum. And in honor of the big episode, we’re taking a look at the stars who made NCIS what it is today from way back when to now. Click through the gallery above for them all!

NCIS, 350th Episode airs Tonight, Tuesday, April 17, 8/7c, CBS