The Gallaghers Are Back in the ‘Shameless’ Season 10 Premiere (PHOTOS)

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William H. Macy as Frank Gallagher in a walker in Shameless - 'We Few, We Lucky Few, We Band of Gallaghers!'
Paul Sarkis/Showtime

William H. Macy as Frank Gallagher

William H. Macy as Frank Gallagher at the doctor in Shameless - 'We Few, We Lucky Few, We Band of Gallaghers!'
Paul Sarkis/SHOWTIME

William H. Macy as Frank Gallagher

Emma Kenney as Debbie Gallagher in Shameless - 'We Few, We Lucky Few, We Band of Gallaghers!'
Paul Sarkis/Showtime

Emma Kenney as Debbie Gallagher

Emma Kenney as Debbie Gallagher and William H. Macy as Frank Gallagher in Shameless - 'We Few, We Lucky Few, We Band of Gallaghers!'
Paul Sarkis/Showtime

Emma Kenney as Debbie Gallagher and William H. Macy as Frank Gallagher

Emma Kenney as Debbie Gallagher in Shameless - 'We Few, We Lucky Few, We Band of Gallaghers!'
Paul Sarkis/SHOWTIME

Emma Kenney as Debbie Gallagher

William H. Macy as Frank Gallagher and Luis Guzman as Mikey O in Shameless
Paul Sarkis/SHOWTIME

Luis Guzman as Mikey O and William H. Macy as Frank Gallagher

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Paul Sarkis/SHOWTIME

Jess Gabor as Kelly, Ethan Cutkosky as Carl Gallagher, ChristianI Isaiah as Liam Gallagher, Steve Howey as Kevin Ball, Jeremy Allen White as Lip Gallagher, Shanola Hampton as Veronica Fisher, Emma Kenney as Debbie Gallagher, William H. Macy as Frank Gallagher and Luis Guzman as Mikey O

Shameless - Ethan Cutkosky as Carl Gallagher and Jess Gabor as Kelly
Paul Sarkis/SHOWTIME

Ethan Cutkosky as Carl Gallagher and Jess Gabor as Kelly

Ethan Cutkosky as Carl Gallagher and Jess Gabor as Kelly in Shameless
Paul Sarkis/SHOWTIME

Ethan Cutkosky as Carl Gallagher and Jess Gabor as Kelly

Ethan Cutkosky as Carl Gallagher in Shameless - We Few, We Lucky Few, We Band of Gallaghers!
Chuck Hodes/SHOWTIME

Ethan Cutkosky as Carl Gallagher

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Chuck Hodes/SHOWTIME

Steve Howey as Kevin Ball

Steve Howey as Kevin Ball in Shameless
Chuck Hodes/SHOWTIME

Steve Howey as Kevin Ball

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Chuck Hodes/SHOWTIME

ChristianI Isaiah as Liam Gallagher

Jeremy Allen White as Lip Gallagher on a motorcycle in Shameless
Chuck Hodes/Showtime

Jeremy Allen White as Lip Gallagher

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When Season 10 of Shameless begins on Sunday November 10, the series picks up six months after last season’s finale: Frank (William H. Macy) uses his leg injury to collect as many prescription drugs as possible and his exploits lead him to an old friend.

Debbie (Emma Kenney), emboldened by the $50,000 left to her by Fiona, has stepped in as the new matriarch, ruling over the Gallagher household with an iron fist. Lip (Jeremy Allen White) navigates his relationship with a newly affectionate Tami (Kate Miner). Carl (Ethan Cutkosky) has to decide what to do with his life as he finishes military school and heads back to the South side.

Liam (Christian Isaiah) is committed to learning more about black history and culture under the tutelage of V (Shanola Hampton) as Kev (Steve Howey) faces an identity crisis. Gallavich returns this season as Ian (Cameron Monaghan) and Mickey (Noel Fisher) rekindle their romance in prison as both cellmates and lovers.

Click through the gallery above for a sneak peek at the premiere episode, “We Few, We Lucky Few, We Band of Gallaghers!”

Shameless, Season 10 Premiere, Sunday, November 10, 9/8c, Showtime