Thomas (Dylan OBrien), a teenager, arrives in a glade at the center of a giant labyrinth. Like the other youths dumped there before him, he has no memory of his previous life. Thomas quickly becomes part of the group and soon after demonstrates a unique perspective that scores him a promotion to Runner status -- those who patrol the always-changing maze to find an escape route. Together with Teresa (Kaya Scodelario), the only female, Thomas tries to convince his cohorts that he knows a way out.
Years after the collapse of civilization, the tyrannical Immortan Joe enslaves apocalypse survivors inside the desert fortress the Citadel. When the warrior Imperator Furiosa (Charlize Theron) leads the despots five wives in a daring escape, she forges an alliance with Max Rockatansky (Tom Hardy), a loner and former captive. Fortified in the massive, armored truck the War Rig, they try to outrun the ruthless warlord and his henchmen in a deadly high-speed chase through the Wasteland.
Randall "Memphis" Raines long ago abandoned his life of crime, but after an ominous visit from an old friend, he finds he has no choice but to return to what he does best -- stealing cars -- in order to save his brothers life. It all comes down to one night, 50 cars and a contract.