Ramirez, whose first episode airs Sunday, November 19 (10:30-11:30 PM, ET/10:00-11:00 PM, PT), will play Kat Sandoval, "a brilliant political strategist, legendary in D.C. for her talent and for abruptly dropping out of politics until Elizabeth manages to coax her back into the State Department," according to the network.
Neuwirth confirmed the news via Twitter.
“We’re very excited that Sara is joining the cast,” said Barbara Hall, Madam Secretary EP and creator. “She brings a fresh perspective and a fun, energetic quality to the State Department staff.”
"Can’t wait for you to meet Kat on Nov. 19! #KatSandoval @MadamSecretary #CBS," Ramirez tweeted.
The Tony-winning actress starred for ten seasons on ABC's long-running medical drama Grey's Anatomy as Dr. Callie Torres. She left the series in 2016.
Madam Secretary stars Téa Leoni, Tim Daly, Zeljko Ivanek and Keith Carradine.
Madam Secretary, Sundays, 10/9c, CBS