Dr. Gregory House (House)
House (Hugh Laurie), might save your life with his brilliant diagnoses, but he’d make you wish you’d never been born before he was done with you. House seemed to loathe all his patients and everyone else at fictional Princeton-Plainsboro Teaching Hospital, except for his friend Wilson (Robert Sean Leonard), whom he tormented in a twisted show of affection. The egotistical doc also played pranks and pitted his team against one another in ways that were anything but funny except to himself. And over eight seasons, audiences tuned in less for his brains than for his shocking behavior, which could only be (partially) explained by the constant pain he suffered from a poorly healed leg wound.